Azithromycin causes creatinine elevation is mainly considered for drug-induced acute kidney injury. Generally, we will consider immediately stopping the drug, dynamic review, and if necessary, further puncture biopsy and other tests, and then targeted to give drugs and other treatments. Azithromycin belongs to macrolide antibiotics, for clear azithromycin-related creatinine elevation, usually suggests that azithromycin-induced drug-induced renal injury, in this case, the general priority is to consider stopping azithromycin immediately continue to use. Secondly, dynamic monitoring of creatinine, uric acid and other renal function indexes changes, generally after stopping the drug creatinine can be restored to the normal range in a short period of time. For persistent abnormal or even progressive elevation of creatinine level, if necessary, we should consider further improvement of relevant examinations, such as renal puncture pathology test, in order to clarify the type of pathology associated with renal injury, such as acute glomerulonephritis, nephrotic syndrome, etc., and then targeted treatment, and hemodialysis and other adjuvant treatments should be considered if necessary. It is recommended that patients with drug-induced creatinine elevation should go to the hospital in time and be treated actively under the guidance of the doctor to avoid the development of the disease.