Fifty years old not having a period after taking Deferiprone tablets is not necessarily menopausal, and there are more reasons for menopause, such as low hormone levels and pituitary gland pathology. Patients usually do not cause vaginal bleeding when taking oral dydrogesterone tablets, but withdrawal bleeding may result after stopping dydrogesterone tablets for a few days. Withdrawal bleeding usually requires a certain level of estrogen to occur; patients in the menopausal transition have decreased ovarian function and fluctuating estrogen secretion; when estrogen secretion decreases, dydrogesterone alone will not result in the onset of menstruation. The endocrine axis that controls menstruation in women is hypothalamus-pituitary-ovary, and amenorrhea may occur when there are lesions in the hypothalamus, pituitary, or ovaries, such as craniopharyngiomas, pituitary tumors, and so on. Patients who experience amenorrhea need to consult a doctor and under the doctor’s guidance, complete the examination to clarify the cause of amenorrhea and determine whether treatment is needed.