Norethindrone is a progestin and medroxyprogesterone is a steroid, and the indications, adverse effects, and contraindications of the two drugs are different, so it is not possible to compare which one is better. Norethindrone is mainly used for the treatment of irregular menstruation, functional uterine bleeding, endometriosis, and contraception, etc. Common adverse reactions include nausea, vomiting, fatigue, and withdrawal bleeding, etc. It is generally prohibited to use it in people with severe hepatic or renal impairment and in those who are pregnant. Medroxyprogesterone is mainly used for the treatment of abnormal uterine bleeding, breast cancer, endometrial cancer, renal cell carcinoma and so on. Its common adverse reactions include abnormal uterine bleeding, breast tenderness, thromboembolic disease, nausea, cholestatic jaundice, allergic reactions, and edema. It should be contraindicated in those with active thrombosis, liver injury disorders, and suspected pregnancy. In addition, both norethindrone and medroxyprogesterone should be used under medical supervision.