Dizziness after SLE treatment may be caused by adverse drug reactions, but it may also be caused by SLE complicated with lupus encephalopathy, pulmonary hypertension, etc. The causes of dizziness should be further clarified and adjusted accordingly to the medication regimen, drug therapy and other countermeasures. 1. Adverse drug reactions: Commonly used drugs for SLE include non-steroidal anti-inflammatory drugs such as etoricoxib and ibuprofen, anti-malarial drugs such as hydroxychloroquine, and immunosuppressive drugs such as methotrexate and azathioprine, etc. Some of these drugs may cause dizziness, headache and other adverse drug reactions, which should be treated according to the severity of the adverse drug reactions to alleviate the symptoms or to adjust the drug treatment plan. 2. Lupus encephalopathy: Systemic lupus erythematosus can involve the patient’s brain and lead to headache, dizziness, hallucinations and seizures, etc. Methylprednisolone, prednisone and other glucocorticosteroids, or furosemide, spironolactone and other diuretics and other medications can be used for the treatment, and at the same time, the patient is advised to have bed rest and to control the amount of liquid intake. 3. Pulmonary arterial hypertension: SLE complicating with pulmonary arterial hypertension can lead to shortness of breath, fatigue, dizziness and other symptoms after activities, in this case, glucocorticosteroids such as prednisone, immunosuppressant such as tacrolimus and other medications should be maintained and actively given symptomatic treatment. There may be other reasons for the dizziness after SLE treatment, so patients are advised to go to the rheumatology department of regular hospitals in time to further clarify the cause of the disease and follow the doctor’s instructions, and do not use medication on their own.