Drinking alcohol while taking HIV blocking medication can affect the effectiveness of the medication. HIV generally refers to the human immunodeficiency virus, and human immunodeficiency virus blocking drugs are medications that are taken within 72 hours of the presence of high-risk behaviors for having HIV, thus blocking the virus from infecting the body. Commonly used HIV blocking medications include raltegravir and tenofovir ester Due to the interaction between alcohol and human immunodeficiency virus blocking drugs, as well as the effect of alcohol on the liver function of the drinker, etc., it may cause changes in drug concentration, affecting the efficacy of the drug, hindering the blocking effect of the drug, and in severe cases, may lead to failure of blocking. Alcohol consumption may also aggravate the adverse effects of the drug, such as dizziness, headache, general weakness, diarrhea, dyspnea, skin rash and other symptoms. Patients are advised to avoid alcohol intake during the period of taking HIV blocking medication, they should have a regular routine and a balanced diet, and they can eat fresh fruits and vegetables appropriately. At the same time, keep a positive and optimistic mindset.