Whether AIDS or syphilis 2 weeks, 3 weeks and 26 days are negative can not be completely excluded from the infection, the existence of high-risk behaviors need to be reviewed after 6 weeks and 3 months, are negative can basically rule out infection. The average window period for HIV and syphilis is 4 to 6 weeks, i.e., a negative test at 6 weeks can rule out most infections. However, there are individual differences in the window period, and the window period of a few patients can be up to 3 months. Therefore, if the test is negative after high-risk behavior, it is recommended that a retest be conducted after 6 weeks and 3 months, and if both tests are negative, the possibility of infection can be basically ruled out. In summary, due to the large difference in the window period, it is recommended to review the diagnosis 6 weeks and 3 months after high-risk behavior to completely exclude infection. It is recommended to take protective measures and avoid high-risk sexual behaviors to reduce the chance of infection and transmission.