Liver pox refers to hepatomegaly, which can be clinically cured with aggressive treatment, but not cured. Hepatomegaly is a chromosomally recessive disorder of copper metabolism with familial inheritance, which can be manifested by pain in the liver area, nausea and vomiting, tremors, cognitive impairment, mental disorders and so on. Because it is a disorder of copper metabolism caused by genetic variations, it cannot be completely cured. Clinically, drugs combined with dietary control are often used to treat hepatomegaly, such as the use of dimercaptopropanol, penicillamine, zinc sulfate, etc. to promote the excretion and absorption of copper, and dietary attention is paid to eating less copper-containing foods, such as fish and shrimp, animal offal and nuts. Usually, with active treatment, clinical cure can be achieved, and long-term treatment can improve the prognosis. Liver transplantation can be considered if the disease progresses to the decompensated stage of cirrhosis. When hepatomegaly occurs, one should consult a doctor as early as possible and standardize the treatment under the doctor’s guidance in order to control the disease and improve the quality of life.