Although no cancer cells are detected in abdominal fluid of liver cancer, the presence of abdominal fluid suggests that it has already reached the advanced stage. According to the clinical staging of primary liver cancer, the presence of ascites, jaundice, distal organ metastasis and other clinical symptoms indicates that it has already reached the third stage, which is the advanced stage. The prognosis is generally poor and the survival rate of 3-6 months is low. Interventional embolization and perfusion chemotherapy should be preferred in this period, generally about 2-3 times, and depending on the improvement of the disease and the patient’s tolerance, to see whether it is necessary to give subsequent intravenous chemotherapy. Genetic testing is also possible to select sensitive chemotherapy drugs and targeted drugs. The drugs usually taken are Sorafenib and Apatinib, and the cycle of taking them is recommended to be about 3-6 months. It is recommended to be hospitalized in hepatobiliary department in time, complete the relevant examination under the guidance of the doctor, and in the daytime to keep a relaxed mood, pay attention to the diet structure, and appropriate physical exercise to enhance the physical fitness and prolong the life.