Mild to moderate renal insufficiency can take febuxostat, severe renal insufficiency need to be used with caution. Febuxostat is a kind of uric acid medicine, mainly used for the treatment of hyperuricemia, gout, the mechanism of action is to inhibit xanthine enzyme, and then inhibit the production of uric acid, febuxostat side effects are less for the liver and kidney function have less impact, the degree of renal insufficiency can be normal service use of the patients, severe renal insufficiency patients should be used with caution. Febuxostat is contraindicated in patients receiving azathioprine, mercaptopurine treatment, in addition, there are some adverse reactions need to pay attention to: abnormalities in liver function, such as aminotransferases, bilirubin elevation, etc.; allergic reactions, such as rash, itching, etc.; gastrointestinal reactions, such as diarrhea, nausea, etc.; cardiovascular system manifestations, such as panic, chest pain; musculoskeletal system, such as joint pain, muscle spasms, etc.. Febuxostat should be used in accordance with medical advice, avoid unauthorized use of medication, so as not to aggravate the condition. It is recommended that patients with renal insufficiency go to a regular hospital in time for standardized treatment under the guidance of a physician.