Walking for a long time with swollen feet and swollen hands are common causes of overexertion, hypoproteinemia, cardiovascular disease, kidney disease and so on. 1. Excessive exertion: walking for a long time can cause the body to be overworked, resulting in a large accumulation of lactic acid or obstruction of venous return, which can cause swelling. 2. Hypoproteinemia: due to long-term malnutrition, insufficient protein intake or excessive protein loss, etc., causing low albumin content in the blood and reduced colloid osmotic pressure of plasma, which can cause tissue swelling and symptoms of swollen hands and feet. 3. Cardiovascular diseases: such as right heart failure, which can cause stagnant blood in the body circulation and elevated venous pressure, which can lead to swelling of the limbs, mostly accompanied by symptoms such as chest tightness and shortness of breath. 4. Kidney disease: due to the deterioration of renal filtration rate capacity, urine reduction or a large amount of protein excreted with urine, resulting in hypoproteinemia can cause edema. Swollen hands and feet are caused by a variety of reasons, may also be related to blood clots, cirrhosis and other diseases, if the symptoms continue to be unrelieved, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, targeted treatment.