High gamma-glutamyl transpeptidase may be caused by alcohol consumption, obstructive biliary tract disease, liver disease (acute and chronic hepatitis, cirrhosis, fatty liver, etc.), pancreatic disease, and so on. 1. Alcohol consumption: long-term alcohol consumption can lead to high gamma-glutamyl transpeptidase. 2. Obstructive biliary tract diseases: for example, chronic cholestasis caused by sclerosing cholangitis and intrahepatic obstruction caused by hepatocellular carcinoma can result in the production of large amounts of γ-glutamyl transpeptidase by liver cells. 3. Liver diseases: (1) acute and chronic hepatitis: including hepatitis A, hepatitis B, hepatitis C, alcoholic hepatitis, drug hepatitis, can cause liver necrosis and thus lead to hepatocytes, hepatocytes acylase synthesized antibody hyperactivity can also lead to high γ-glutamyl transpeptidase. (2) Cirrhosis: causing liver function damage can also lead to elevated γ-glutamyl transpeptidase. (3) Fatty liver: Fatty liver affects liver function, which can lead to high γ-glutamyl transpeptidase. (4) Pancreatic diseases: pancreatitis, pancreatic tumor can also cause high γ-glutamyl transpeptidase. It is recommended that patients go to regular medical institutions, standardized treatment under the guidance of physicians.