Methylcobalamin belongs to vitamin drugs, while glutamine is extracted from cereals as a binding lipid component, the two pharmacological mechanism, indications, contraindications, etc. are different. Methylcobalamin is composed of vitamin B12, which has the role of nutritional nerve, but also exogenous supplementation of vitamin B12, mainly used for peripheral neuropathy, vitamin B12 deficiency caused by megaloblastic anemia and so on. Its side effects include rash, vomiting, diarrhea, etc. It is contraindicated for those who are allergic to methylcobalamin. Glutamine is a natural ingredient extracted from cereals, which has the effect of regulating the dysfunction of plant nerves and endocrine balance disorders, and is clinically used in premenstrual tension syndrome, neurosis, and menopausal syndromes, such as sedation and insomnia. Its side effects include nausea, vomiting, dry mouth, hair loss, etc. It is prohibited for those who are allergic to this product. Methylcobalamin and glutamine belong to two kinds of drugs, the difference is big, it is recommended to choose the right drug according to the situation under the guidance of the doctor, and should not be used blindly.