Thinning skin with depression may be caused by natural aging, muscle atrophy, depressed scarring, etc. Thinning skin with depression can be treated with dietary care, acupuncture, medication, etc. under the guidance of a doctor. 1. Natural aging: Natural aging of the skin due to broken collagen fibers and fat loss can lead to thinning of the skin with depression, which can be treated with autologous fat and hyaluronic acid filler, or facelift surgery. 2. Muscle atrophy: Muscle atrophy patients may have muscle tissue adhesion, which is more likely to lead to the human body has thinning skin with the symptoms of depression. You can use acupuncture under the guidance of a professional doctor to stimulate the muscle atrophy, which can make the muscle nerves active and relieve the muscle atrophy. 3. Sunken scar: Sunken scar is a kind of scar produced when the dermis or subcutaneous tissue of the skin is damaged, and this kind of scar will make the patient’s skin become thin and have a sunken condition. Fractional laser treatments can be performed or autologous lipofillers can be used to flatten the depressions. Thinning of the skin with indentations requires prompt medical attention and standardized treatment under the supervision of a doctor.