Clinically, there is no such thing as “three nemeses that gray nails are most afraid of”. Gray nails, also known as onychomycosis, are mainly treated by oral medication and topical medication in the clinic. 1. Oral drug treatment: patients with onychomycosis can take oral antifungal drugs as prescribed by the doctor, such as terbinafine hydrochloride tablets, itraconazole tablets and other antifungal treatment. 2. Topical drug treatment: patients with onychomycosis can use topical antifungal drugs such as amorphophallus powder and cyclopiazepoxide nail coating under doctor’s guidance. It is worth noting that, for some stubborn patients, you can first carry out nail extraction, and then oral antifungal drug treatment, but after the extraction of the nail should pay attention to protect the cleanliness and hygiene of the traumatic surface, and then prevent infection. For refractory onychomycosis patients can also try to use photodynamic therapy under the guidance of the doctor. It is recommended that patients with onychomycosis go to the hospital in time, and standardize the treatment under the guidance of the doctor, so as not to delay the condition.