Gastroscopic biopsy of squamous epithelial simple hyperplasia 25 to 30 cm from the incisors, but no symptoms, mostly not serious, it is recommended to review regularly to avoid progression of the disease. Squamous epithelial simple hyperplasia in the thoracic section of the esophagus 25-30 cm from the incisor may be a normal physiological phenomenon, or it may be a benign lesion of the esophagus caused by pathological factors, which is most commonly seen in reflux esophagitis in clinical practice. 1. Normal physiological phenomenon: The squamous epithelial cells on the surface of the normal esophagus will show protective hyperplasia due to the friction of food during eating, which is a normal physiological phenomenon for the process of repair and recovery. 2. Reflux esophagitis: it is due to the reflux of gastric juice into the esophagus, causing chronic inflammatory changes in the esophageal mucosa, and pathological tissue can be found in the esophageal mucosa squamous epithelium mild hyperplasia. The above conditions should be treated promptly by a professional physician to assess the severity of the disease and standardize the treatment.