There is no fastest way to get rid of edema of the lower limbs, and it needs to be treated according to the cause of the disease. There are many causes of lower limb edema, such as heart disease, kidney disease, liver disease, etc., which need to be treated with medication according to different causes. 1. Heart disease: for example, the most common in heart failure, patients with heart failure can appear lower extremity edema along with chest tightness, panic, shortness of breath and so on. Under the guidance of a physician, hydrochlorothiazide tablets, digoxin tablets and other drugs can be used, while the causes of heart failure should be treated. 2. Kidney disease: for example, suffering from nephrotic syndrome, proteinuria, swelling, high blood pressure and so on. It can be treated by applying spironolactone tablets, hormones and other drugs. 3. Liver diseases: for example, suffering from liver cirrhosis or liver cancer, etc., which can be manifested as swelling of the lower limbs, ascites, loss of appetite, pain in the liver area, etc., and can be treated by applying albumin and supporting symptomatic treatment. In addition to the above diseases, there are many other causes of lower limb edema, which need to go to the hospital and get a clear diagnosis of the cause of the disease and then carry out targeted treatment.