There are no pain nerves in the normal liver parenchyma, only the hepatic periosteum (i.e., a layer of membrane covering the surface of the liver) is rich in pain nerves. We often hear that the liver is a “silent organ”, is because there is no pain nerve in the liver parenchyma, some small lesions occur, there is no pulling, damage to the liver periosteum when the liver will not feel the pain in the liver area. Only when the lesion injures the periosteum, or when the lesion pulls on the periosteum of the liver, will the sensory nerve be stimulated, causing distension and dull pain in the liver area. It is because of this characteristic of the liver that patients with chronic hepatitis or cirrhosis are advised to undergo regular checkups to detect possible early cancerous changes in the liver.