An adult alkaline phosphatase of 185 U/L, which is above the normal range, suggests that a liver, gallbladder or bone disease may be present, but the severity should not be considered from the value alone, and medical attention should be sought as soon as possible to determine the cause. Alkaline phosphatase is often used clinically to diagnose liver, gallbladder, or bone disease. The normal range for alkaline phosphatase in adults is 40-150 U/L. If alkaline phosphatase is pathologically elevated and accompanied by abnormal biochemical indicators such as calcium, phosphorus, parathyroid hormone and calcitonin, as well as symptoms such as changes in bone quality, bone deformities and bone pain, it suggests that fibrous bone disease, osteoporosis, rickets, etc. may be present. If alkaline phosphatase is elevated, along with abnormal aminotransferase results, fatigue, weight loss, jaundice, liver and spleen enlargement, etc., it may indicate cholangitis, hepatitis, hepatocellular carcinoma and other diseases of the hepatobiliary system. Elevated alkaline phosphatase is recommended to consult a doctor to identify the cause of the disease and to have targeted treatment or therapy.