The whitening of the skin on both sides of the pubic area is usually treated with medication, and may be caused by mossy vulvar leukoplakia, vitiligo and other reasons. 1. mossy vulvar leukoplakia: mossy vulvar leukoplakia may be related to heredity, autoimmune, endocrine and other factors, preferably in the vulva, and in severe cases, it will involve the vulva and the skin around the anus, which manifests itself as a thickening of the skin at the site of the lesion, hardening, loss of skin color, atrophy and other symptoms. The topical glucocorticoid drugs, such as hydrocortisone cream, can be used topically, can also be used topically immunosuppressants, such as tacrolimus ointment. 2. Vitiligo: Vitiligo may be related to genetic, autoimmune system diseases and other factors, mainly in the face, neck, hands and other parts of the body, can also involve the pubic area, anus, groin and other parts of the body, the performance of the skin surface appeared in different sizes of white patches. Mometasone furoate cream, tacrolimus ointment, carbotriol ointment can be used topically. All of the above drugs should be used under the guidance of a professional doctor, avoid self-medication. There may be other causes for the whitening of the skin on both sides of the pubic area, so it is recommended to go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause.