Granulomas of wounds usually cannot heal by themselves, but they can be cured by medication, laser, and surgery. Granuloma usually occurs in chronic inflammation, due to bacteria, spirochetes, parasites, foreign bodies, etc. into the body, by the macrophage phagocytosis can not be degraded, in the stimulation of inflammation gradually become multinucleated giant cells or epithelioid cells. In general, granulomas are difficult to heal on their own, but they can be treated. In the early stage of granuloma, it can be cured by antibiotics and other medications; if the granuloma is on the surface of the skin, it can also be treated with topical medications or laser therapy; when there is pus inside the granuloma, it needs to be extracted; if the granuloma develops to the later stage, it can be removed by surgery.