Most of the results of paraffin pathology and frozen pathology do not differ much, but there may be some differences in the results due to time constraints, limitations on the number of samples taken, and the effect of preparation.
1. Time constraints: intraoperative frozen pathology reports are issued with time constraints, and generally need to be issued in about 30 minutes, whereas postoperative routine paraffin pathology reports have less time constraints, and generally need to be issued in 5-10 days. The rushed test time may lead to errors in the frozen pathology test, making the results fall short of the paraffin pathology report.
2. Limitation of the number of materials: intraoperative frozen pathology report to shorten the test time, the number of materials taken is limited, the amount of tissue extracted is less, while the postoperative paraffin pathology report is available for more test materials. The limitation of the number of tissues extracted is also easy to lead to intraoperative frozen pathology testing, and there is a leakage or misdiagnosis, which makes it different from the results of the postoperative paraffin pathology report.
3. Preparation effect: Frozen pathology reports are mainly prepared by freezing the sections without effective dehydration, while paraffin pathology reports need to be prepared by sectioning after sufficient dehydration, which is more conducive to the observation of the tested tissues.
Therefore, there is a difference in accuracy between the two, with paraffin pathology reports having an accuracy rate of up to 98% and frozen pathology reports having an accuracy rate of about 95%.
If there is a large difference between the test results of the postoperative paraffin pathology report and the intraoperative frozen pathology report, the results of the postoperative paraffin report are usually used as the main reference.