Waking up with eye pain may be caused by conjunctivitis, blepharitis, increased intraocular pressure and other reasons. 1. Conjunctivitis: Microbial infection or external stimulation of the conjunctiva may lead to conjunctivitis, which may be manifested as photophobia and tearing of the eyes, pain in the eyes, and loss of vision. Patients can use cefixime dispersible tablets, fluconazole eye drops and other drugs under the guidance of the doctor for treatment. 2. Blepharitis: Blepharitis, also known as granuloma, is an acute purulent inflammation of the eyelid glands, with clinical symptoms of redness, swelling, heat, hardness and tenderness. You can use levofloxacin eye drops, erythromycin ophthalmic ointment and other drugs for treatment. 3. Increased intraocular pressure: After the elevation of intraocular pressure, it will stimulate the terminal receptors of the nerves in the eye, and the patient can feel the eyeball swelling and pain. Prolonged maintenance of lying down or inverted position can lead to increased intraocular pressure, but generally transient elevation of intraocular pressure, change to a comfortable position can be recovered. In addition, increased intraocular pressure can also be seen in some eye diseases, such as eye tumors, eye trauma, glaucoma, etc., this time should be timely medical care. Waking up with eye pain can also be seen in other causes, it is recommended that patients seek medical attention in a timely manner, under the diagnosis and guidance of a professional doctor for treatment, do not take medication without authorization.