Hypothyroidism patients with autoimmune inflammatory diseases, serious infections and other serious conditions, can be treated with dexamethasone, common side effects are gastrointestinal discomfort, centripetal obesity, osteoporosis, etc., the use of medication should be under the guidance of a doctor. Dexamethasone is an adrenocorticotropic hormone drug that can play an anti-inflammatory, anti-allergic role, mainly used in the treatment of allergic and autoimmune inflammatory diseases, serious infections and other diseases, hypothyroidism patients with indications can be used under the guidance of a doctor. Patients with hypothyroidism can use it under doctor’s supervision if they have indications. It is contraindicated in patients who are allergic to this drug and other glucocorticosteroids, have a history of serious mental illness, or have active peptic ulcers. Dexamethasone should be used with caution in patients with hypothyroidism. The use of dexamethasone may cause gastrointestinal discomfort such as nausea and vomiting, neuropsychiatric symptoms such as insomnia and euphoria, endocrine symptoms such as centripetal obesity and hypoglycemic intolerance, as well as adverse reactions such as osteoporosis, bone fracture, acne, and so on. Patients with hypothyroidism who need to use dexamethasone should use the drug under the guidance of a doctor.