The probability of relapse 10 years after cure of childhood leukemia cannot be clearly judged, but mainly depends on a variety of factors such as the degree of leukemia progression, risk stratification, and whether the patient has serious complications. 1. If the leukemia progresses slowly and there are no serious complications, the recurrence rate after 10 years is generally lower, but on the contrary, the probability will be higher, and the patient needs to be actively reviewed and followed up. 2. If leukemia belongs to the prognostic high-risk group, the risk of relapse is higher, and the risk of relapse is lower in the intermediate-risk and low-risk groups. Leukemia is a malignant clonal disease of hematopoietic stem cells, mainly caused by genetic, chemical, biological and other factors, may have anemia, bleeding, infection and other symptoms, the onset of disease is acute, the course of the disease is short, if found in a timely manner to treat, the main treatment for chemotherapy, hematopoietic stem cell transplantation therapy, targeted drug therapy and so on. The main treatment methods are chemotherapy, hematopoietic stem cell transplantation, targeted drug therapy, etc. The drugs mainly include cytarabine, Zoerythromycin, cyclophosphamide, vincristine, etc. Specific diagnosis and treatment need to be carried out under the guidance of physicians.