Tetanus immune globulin is usually safe and vaccination greatly reduces the risk of tetanus infection in people with an incomplete history of tetanus immunization. If there is a contaminated wound, it is recommended to seek medical attention and use tetanus toxoid vaccine or immune globulin as prescribed. Tetanus immunoglobulin is a passive immunization preparation, classified as human tetanus immunoglobulin and equine tetanus immunoglobulin, with antibodies to the tetanus toxin as the main component, and can be used for short-term passive immunization for the prevention and treatment of Clostridium tetani infection. Human tetanus immunoglobulin is usually safer, and the main adverse reaction to equine tetanus immunoglobulin is anaphylaxis, so an allergy test is required prior to use, and human tetanus immunoglobulin should be used instead if positive. In the presence of contaminated wounds, short-term passive immunity can be obtained after tetanus immunoglobulin administration, which can greatly reduce the risk of tetanus in people who have not received the full course of tetanus vaccination.