High glutamyl transferase may be caused by physiologic factors, liver diseases, biliary tract obstructive diseases, pancreatic diseases and so on. 1. Physiological factors: Liver injury may be caused by irregular diet, exertion, staying up late, alcoholism, etc., which may result in high glutamyl transferase. 2. Liver diseases: Since glutamyl transferase is mainly found in liver cells, if you suffer from liver diseases such as hepatitis, fatty liver, cirrhosis, etc., it may lead to the loss of cells in the liver and high glutamyl transferase. 3. Obstructive biliary tract diseases: If you suffer from biliary tract diseases such as cholecystitis, gallstones, etc., it may lead to obstruction of gallbladder ducts and bile ducts, which may cause obstruction of excretion of bile and glutamyltransferase, and then high glutamyltransferase may appear. 4. Pancreatic diseases: If you suffer from pancreatic diseases, such as pancreatitis, pancreatic tumors, etc., they may have certain effects on the liver, thus causing elevated glutamyl transferase. Patients with high glutamyltransferase should go to the hospital in time to check the cause of the disease and take active treatment under the guidance of the doctor.