Neonatal adrenocortical hyperplasia is a serious disease that may threaten the life of the child if not diagnosed early and treated regularly. Neonatal adrenocortical hyperplasia is a congenital disease, belonging to the autosomal recessive genetic disease, mainly manifested as a series of symptoms caused by adrenocorticotropic hormone synthesis disorders, such as recurrent vomiting, diarrhea, hyponatremia, hyperkalemia, metabolic acidosis, and in severe cases, circulatory failure, and other critical conditions, which can threaten the lives of newborns. Children with less severe symptoms may develop precocious puberty, hirsutism, acne, hypomenorrhea, and impaired fertility as they grow into childhood and adolescence. If glucocorticoids or saline corticosteroids are supplemented promptly at birth, the normal physiological metabolism of the body can be maintained, preventing the development of such symptoms in affected children. Therefore, newborns with adrenocortical hyperplasia should go to the hospital for timely consultation and early treatment to avoid further development of the disease. The above drugs should be used under the guidance of a doctor, avoid self-medication.