Can plasma cells proliferate and differentiate?

Plasma cells are not capable of further proliferation and differentiation, they are end-of-differentiation immune cells and do not have the ability to further proliferate and differentiate. Plasma cells are differentiated from immune B-lymphocytes under antigenic stimulation, and are mostly found in the connective tissues of the digestive or respiratory tracts. Plasma cells are small, with coarse chromatin, arranged in a wheel-like radial pattern, and have the function of synthesizing and storing antibodies. Abnormal proliferation of B-lymphocytes in the body will lead to abnormal quality and quantity of plasma cells, which will cause multiple myeloma, primary amyloidosis, plasma cell leukemia, etc., and sepsis, dizziness, vertigo, impaired consciousness and other symptoms may also occur. When uncomfortable symptoms appear in the body, one should go to the hospital in time for relevant examination to clarify the cause of the disease and carry out regular treatment as early as possible under the guidance of physicians.