Dapoxetine hydrochloride can be taken on an empty stomach. Dapoxetine hydrochloride can be taken on an empty stomach or with a meal, and the tablet should be swallowed whole. Patients are advised to take the medication with at least one full glass of water. Patients should try to avoid injuries caused by prodromal symptoms such as fainting or dizziness and follow the doctor’s instructions. The mechanism of action of dapoxetine hydrochloride may be related to the inhibition of neuronal reuptake of 5-hydroxytryptamine, so that the potential difference between the pre- and post-synaptic receptors of the nerve cell is altered, thus inhibiting the conduction of nerve excitation. The drug is used to treat poor ejaculatory control and premature ejaculation, and adverse effects such as dizziness, nausea, diarrhea, headache, fatigue, and upright hypotension may occur after administration. The drug may cause severe reactions such as hyperthermia and myoclonic spasms when combined with monoamine oxidase inhibitors. The drug may also interact with thioridazine, cytochrome P450 3A4 inhibitors such as ketoconazole. Therefore, the drug is contraindicated while using monoamine oxidase inhibitors, thioridazine, or within 14 days of discontinuing the drug; it is also contraindicated while taking potent cytochrome P450 3A4 inhibitors. It is also contraindicated in patients with significant cardiac pathology, moderate to severe hepatic insufficiency, severe renal insufficiency, or hypersensitivity to the drug. Use with caution in patients taking moderate cytochrome P450 3A4 inhibitors or mild to moderate renal insufficiency. If you need to use the drug, please take the drug under the guidance of a doctor and strictly follow the doctor’s instructions, do not use the drug at will.