Nephrotic syndrome usually can’t be cured by itself, it needs to be treated, including proper rest, diuresis and swelling, immunosuppression, prevention of complications, etc. Only some patients with membranous nephropathy can be relieved spontaneously without treatment. Nephrotic syndrome is usually accompanied by large amount of proteinuria, hypoproteinemia, also can cause edema, hyperlipidemia, long-term untreated can be complicated by infection, protein and fat metabolism disorder, thrombosis and embolism, acute kidney injury and other complications. The main treatment is to pay attention to rest, reduce the intake of high-protein diet, can take hydrochlorothiazide, furosemide and other diuretic swelling, at the same time, immunotherapy is needed, often used glucocorticosteroids (such as prednisone acetate), cyclophosphamide, cyclosporine, etc., the specific treatment plan should be based on the type of pathology to choose, and it is recommended that timely treatment to reduce the risk of complications. Clinically, remission, not cure (self-healing), is generally spoken of. Certain membranous nephropathies can be in spontaneous remission without treatment, and the specific time of remission is uncertain. Relevant data show that the complete remission rate of 1 year, 2 years and 3 years is about 10%, 16% and 22%, respectively. It is suggested that patients with nephrotic syndrome should consult regular hospitals in time and standardize the treatment under the guidance of physicians.