Meniere’s disease is a disease of the inner ear with the main pathological basis of membrane labyrinth accumulation. The cause of the disease is still unclear, and it may be related to genetic factors, immune response, and ischemia of the inner ear. 1. Genetic factors: some patients have abnormal internal development of the ear, which affects the normal function of the ear and may induce Meniere’s disease. 2. Immune reaction: Stimulation of the inner ear by antigen-antibody reaction may cause capillary dilatation and increased permeability, allowing body fluids to seep into the membranous labyrinth, leading to accumulation of fluid in the membranous labyrinth and inducing Meniere’s disease. 3. Ischemia of the inner ear: Ischemia of the inner ear may cause vasospasm, resulting in tissue hypoxia and metabolic dysfunction, prompting the external lymph and blood fluid to move into the lymph to form the labyrinth of the inner ear membrane fluid, inducing Meniere’s disease. Overexertion, mental stress, lack of sleep and other reasons may also trigger Meniere’s disease, it is recommended that patients consult a doctor in a timely manner, under the guidance of the doctor to clarify the diagnosis, targeted treatment.