While early poppyine hydrochloride may be addictive, the current artificially extracted poppyine hydrochloride is not addictive. The current clinical application of poppyine hydrochloride is an alkaloid, not extracted from the opium poppy, but synthesized by biological means through artificial chemical synthesis, consistent with the natural composition of poppyine, but not mixed with other addictive ingredients. Earlier poppyine hydrochloride was extracted from the opium poppy and was addictive because it was mixed with addictive ingredients and could not be completely separated clean. However, the current application of synthetic poppyine hydrochloride is particularly safe and non-addictive and narcotic. Mainly non-addictive opiate alkaloids, belonging to the vasodilator, its mechanism of action is to mildly block the calcium inward flow of vascular smooth muscle cell membranes, thus causing non-specific relaxation of smooth muscle in blood vessels, heart or other parts of the body, applied to a variety of ischemic diseases caused by vasospasm, such as lower limb arterial occlusive disease or angina pectoris. Therefore early poppyine hydrochloride may be addictive, while the current artificially extracted poppyine hydrochloride is not addictive. At present, after clear clinical indications, synthetic poppy alkaloids hydrochloride can be used without worry, but when applying them, care needs to be taken to avoid overdosing by sedation or too fast, otherwise it may lead to atrioventricular block, ventricular fibrillation, or even death, and care needs to be taken to check liver function during use to avoid causing drug-related liver injury, especially in patients suffering from gastrointestinal symptoms or jaundice.