The main symptom of liver cancer is called subclinical hepatocellular carcinoma, which has a relatively insidious onset and often lacks typical symptoms and signs except positive serum AFP in the early stage. Most of the patients in subclinical stage are found to have symptoms in census or long-term follow-up observation of chronic liver disease, and most of them have already entered into advanced stage, and its main symptom is pain in liver area as one of the most common symptoms. Cancer above the right lobe of the liver may invade the diaphragm and cause right shoulder or right back pain. Another symptom of middle and late stage is hepatomegaly, which can be protruded under the right rib arch or shoulder eminence when the mass grows downward, and can move upward when it grows upward towards the diaphragm. As the arterial vessels of hepatocellular carcinoma are rich, some of them suddenly become thin and huge cancer mass compresses the neighboring arteries, which may cause blowing-like vascular murmur to be heard locally. The other is the sign of cirrhosis, and then the systemic manifestation.