There are more causes of pain in the middle of the knee, such as osteoarthritis of the knee joint, synovitis of the knee joint, meniscus injury of the knee joint, etc. Treatment should be based on the causes of pain in the middle of the knee, and the treatment usually includes medication, physical therapy, surgery, etc. 1. Osteoarthritis of the knee joint: degenerative lesions and osteophytes occur in the cartilage of the knee joint, and pain, swelling and stiffness will occur in the knee joint. Topical or oral medications such as flurbiprofen gel paste, celecoxib, ibuprofen, etc. can be used. Physical therapy includes hydrotherapy, cold therapy and heat therapy. Surgery can be considered for severe cases. 2. Knee synovitis: related to knee degeneration and joint injury, often manifested as knee swelling, pain, and activity limitation. Patients can take oral celecoxib, etoricoxib, methotrexate, or external flurbiprofen gel paste. Physical methods such as ultrashort wave and spectrum can also be used for treatment. Surgery should be considered if the disease does not resolve with conservative treatment. 3. Knee meniscus injury: sprains may cause knee meniscus injury, often manifested as knee pain, swelling and other symptoms. If the pain and swelling are obvious, topical or oral medicines can be used to reduce swelling and pain, such as Yunnan Baiyao aerosol, safflower oil, celecoxib and so on. Treatment is based on surgery, such as meniscus suture, meniscoplasty, meniscus replacement. Middle knee pain may also have other causes, such as prepatellar bursitis, chondromalacia patella, etc. It is recommended to go to the hospital in time to find out the cause of the problem and treat it according to the cause of the disease, and the above medicines are recommended to be used under the guidance of a doctor. The above drugs should be used under the guidance of a doctor, avoid self-medication.