Benign breast nodules can be vaccinated with New Crown III, but patients who are malignant and undergoing chemotherapy are advised to avoid vaccination for a short period of time. For benign breast nodules, a booster dose of the New Crown III vaccine can be given. Therefore, for patients with benign breast nodules who meet the requirements for vaccination and have no contraindications to vaccination, they can receive the vaccine according to the regulations, and they should be observed for half an hour after vaccination without any adverse reactions such as redness, swelling, dizziness, and so on, before leaving. Some patients with malignant breast nodule manifestation, if they are adopting active measures such as radiotherapy, should temporarily avoid vaccination according to their conditions to prevent aggravating their adverse reactions. Care should be taken to consult the prevention center before receiving the third booster shot, and temporarily avoid vaccination for a short period of time if you are on medication or have a fever.