Gastrografin, or metoclopramide, and morphine, or domperidone, differ in composition, application, adverse effects, contraindications, and precautions. Metoclopramide is an antiemetic drug used for symptomatic treatment of nausea, vomiting, belching (hiccups), dyspepsia, flatulence, and hyperacidity due to various etiologies. The more common adverse reactions to metoclopramide are lethargy, restlessness, and fatigue. It is contraindicated in patients with epilepsy, gastrointestinal bleeding, mechanical intestinal obstruction or perforation, and pheochromocytoma. The dose must be reduced by at least 60% in patients with severe renal insufficiency, who are prone to extrapyramidal symptoms. Domperidone is a prokinetic agent used for dyspepsia caused by delayed gastric emptying, gastroesophageal reflux, and esophagitis. Occasionally, adverse reactions such as dry mouth, headache, insomnia, nervousness, dizziness, and drowsiness are seen. Contraindicated in patients with mechanical gastrointestinal obstruction, gastrointestinal bleeding, and perforation. Cardiac patients, patients with tumors undergoing chemotherapy, patients with electrolyte disorders need to be careful when applying, there is a risk of aggravating cardiac rhythm disorders. Both of the above medicines need to be used in accordance with medical advice to avoid potential health risks caused by self-administration.