Coughing in the middle of the night can be given first symptomatic treatment to relieve coughing, serious symptoms should be immediately sought medical attention; frequent coughing in the middle of the night, you should go to the hospital and do the relevant examination, in order to clarify the cause of the disease to guide the treatment. Common causes include allergies, respiratory infections and gastroesophageal reflux. 1. Symptomatic treatment: If the cough is caused by improper sleeping position, improve the sleeping position; if it is caused by dry mouth and thirst, drink warm water to relieve it; if it is caused by dry air, humidify the air. If the cough is caused by cold, you can drink cough syrup to relieve the symptoms temporarily. Sudden severe coughing, in the middle of the night should also immediately seek medical attention. 2. Determine the cause of the cough and treat the cause of the cough. (1) Allergy: If the cough is caused by allergy, it is recommended to go to the hospital to check the lung function plus airway provocation test and allergen test, and should also improve the sleeping environment. If necessary, antihistamines such as loratadine, cetirizine and bronchodilators such as budesonide formoterol for inhalation should be used under doctor’s supervision. (2) Respiratory infections: If you have recent respiratory infections, such as colds, pharyngitis, pneumonia or bronchitis, you need to use antibiotics such as cefixime, amoxicillin, etc. under the guidance of your doctor. (3) Gastroesophageal reflux: If you usually have gastroesophageal reflux disease, the refluxed food can easily irritate the pharynx when you lie down, resulting in coughing in the middle of the night, therefore, you can take omeprazole capsules before going to bed. Appropriate elevation of the pillow, dinner should not be too full. Coughing in the middle of the night, may also be a manifestation of cardiac insufficiency, often coughing in the middle of the night, you need to consult a doctor for examination without delay. Treatment and medication should follow the doctor’s instructions.