Topical medications for vitiligo extremities include halometasone ointment, tacrolimus ointment, and tacalcitol ointment. Oral medications, phototherapy, and surgical treatments are also usually available. Vitiligo is a pigmentary disorder that results in loss of pigmentation of the skin and mucous membranes due to destruction of melanocytes in the skin. Vitiligo can occur in any part of the body. Usually, patients with vitiligo lesions on the extremities can use topical glucocorticosteroids such as halometasone ointment, fluticasone propionate ointment, mometasone furoate ointment, etc., under the guidance of a doctor. Secondly, topical calcium-modulated phosphatase inhibitors such as tacrolimus ointment and pimecrolimus cream, as well as vitamin D₃ derivatives such as calcipotriol ointment and tacalcitol ointment, are also needed as prescribed by the doctor. In addition to medications, patients may also take oral medications such as leucovorin tablets, phototherapy, and other therapeutic measures. Skin grafting may be considered if the white patches have not worsened in the past 12 months. Vitiligo is a chronic disease, and patients need to strengthen their daily life management, cooperate with doctors to actively treat the disease, and follow up on time.