Nausea on Metformin Extended-Release Tablets may be caused by an adverse reaction to the medication or may be due to an unclean diet, so it is advisable to consult your doctor. Nausea, vomiting, diarrhea, abdominal pain, metallic taste in the mouth, occasional weakness, fatigue, weight loss, dizziness, and rash may occur after taking Metformin Extended-Release Tablets, which is caused by adverse reactions to Metformin Extended-Release Tablets. Type 2 diabetes with ketoacidosis, hepatic and renal insufficiency, heart failure, acute myocardial infarction, severe infection and trauma, major surgery, clinical hypotension and hypoxia, previous history of lactic acidosis, and allergic to metformin extended-release tablets are prohibited. Patients with diabetes mellitus should maintain a low-sugar, low-fat, low-salt diet in daily life, exercise appropriately, and cooperate with doctors for active treatment. If nausea occurs frequently, patients are recommended to go to the hospital.