Lumbar spine minimally invasive infections may be due to invasion of pathogenic bacteria, rejection of internal fixation, and immunocompromise. Treatment mainly includes drug therapy and surgical treatment. 1. Drug treatment: antibiotic treatment is preferred for patients with relatively mild symptoms of infection. The choice of antibiotics needs to be decided according to the patient’s secretion or blood culture results, or empirical treatment can be carried out, and at the same time, the incision is given to change the dressing treatment. Commonly used antibiotics such as cephalosporins, penicillins, macrolides and so on. The above drugs need to be used under the guidance of doctors, avoid self-medication. 2. Surgery: For patients with severe infection, implantation of internal fixation, systemic symptoms, patients considering osteomyelitis, etc., timely surgical intervention is needed. The purpose of surgery is to remove the infected foci and smooth drainage. Surgical modalities include debridement and drainage, negative pressure suction, and so on. Specific surgical methods need to be decided according to the patient’s original disease. For the same disease, patients with different physical conditions and different stages of the disease, the treatment methods are different, and should be standardized under the guidance of doctors.