Amlodipine benzenesulfonate and chlorosartan hydrochlorothiazide can be taken at the same time, with synergistic antihypertensive effect. Amlodipine benzenesulfonate is a calcium channel blocker, and chlorosartan hydrochlorothiazide tablets is a compound preparation combining angiotensin II receptor antagonist and diuretics, which belong to different mechanisms of antihypertensive drugs, and the combination can increase the effect of blood pressure lowering, and the adverse reactions will not increase significantly. Amlodipine benzenesulfonate adverse reactions include dizziness, headache, edema, fatigue, flushing, palpitations and so on. Patients with severe obstructive coronary artery disease, heart failure, patients with severe hepatic insufficiency, and patients with renal failure need to be contraindicated or used with caution. Chlorosartan hydrochlorothiazide has adverse reactions such as dizziness, diarrhea, and allergies. It is contraindicated in patients who are allergic to any of the components of the drug, anuria, allergy to other sulfonamides, pregnant women. Electrolytes need to be monitored during the use of the drug to avoid hypokalemia. Both drugs need to be used under the guidance of a physician, and should not be used blindly on their own to avoid adverse effects.