There is no such thing as what medication works immediately for intercostal neuralgia. Commonly used medications include carbamazepine, gabapentin, vitamin B1, and methylcobalamin. Intercostal neuralgia is a subjective symptom of the patient, although medication is the main measure of the disease, but there is no such thing as intercostal neuralgia what drugs can work immediately. Doctors will formulate a suitable treatment plan according to the patient’s specific situation. Patients need to follow the doctor’s instructions to apply carbamazepine, gabapentin, phenytoin sodium, ibuprofen, pregabalin and other analgesic drugs, and if it is not effective for carbamazepine and phenytoin sodium, then you need to comply with the doctor’s instructions to apply baclofen. Secondly, patients also need to follow the doctor’s instructions to apply vitamin B1, methylcobalamin, vitamin B6 and other nutritive nerve drugs. In addition to medication, patients can also be treated with physical therapy such as ultraviolet light, ultrasound, microwave, etc., as well as nerve block therapy and surgery. Most patients can control their symptoms and improve their quality of life after active treatment, but patients need to strengthen daily life management and regular follow-up.