Intra-sacral fat accumulation refers to the abnormal thickening of the epidural fat layer in the sacral canal. The pathogenesis of sacral fat accumulation is unknown, and may be related to long-term intake of exogenous steroid hormones, primary Cushing’s syndrome, obesity, etc. It occurs in males, and the epidural fat accumulation in patients is mainly mature adipose tissue, which can be seen as tortuous blood vessels and reticulated fibrous tissue. Sacral fat accumulation in severe cases can be manifested as intermittent claudication, lower limb weakness, radiating pain, saddle area sensory impairment, urinary retention, and so on. General treatments such as weight reduction, bed rest, use of painkillers such as ibuprofen as prescribed by the doctor, and surgical resection if necessary can be used. People with symptoms of fat accumulation in the sacral canal need to consult a doctor in time for a clear diagnosis and active treatment.