The causes of soft granules at the base of the thigh include common warts, lipomas, and condyloma acuminatum. 1. Common warts: If infected by human papilloma virus, these viruses can damage the skin, leading to the proliferation of skin tissues, thus appearing granules. 2. Lipoma: Due to the increase of fat cells caused by a variety of factors, these fat cells gathered in the thigh root can appear meat grain-like material. 3. Condyloma acuminatum: mostly caused by low-risk human papillomavirus infection, manifested as scattered or clustered distribution of papillomatous or coronal skin-colored new organisms, similar to granules. It is a sexually transmitted disease that requires active treatment. Thigh root long soft meat grain may also be other reasons, it is recommended that the symptomatic patients go to the regular hospital in time, by the specialist doctor for standardized diagnosis and treatment.