In the advanced stage of Hashimoto’s thyroiditis with hypothyroidism, the thyroid function is obviously hypothyroid, and hormone replacement therapy is needed, and levothyroxine sodium tablets are commonly used in clinical practice. Attention should be paid to regular rechecking of the thyroid function, and symptomatic treatment can be taken if there are other complicating symptoms. Hashimoto’s thyroiditis is an autoimmune disease, early symptoms are not significant, as the disease progresses to the late stage, a large number of thyroid follicular epithelial cell destruction, resulting in hypothyroidism, thyroid hormone levels are reduced, which can be manifested as fatigue, lethargy, fear of cold, mucous edema. The treatment is mainly to apply levothyroxine sodium tablets for replacement therapy to ensure the normal metabolism of the body. If the patient develops significant enlargement or pain in the thyroid gland, or if there are obvious compression symptoms, surgical resection treatment can be considered. In addition, regular review is required to monitor the thyroid function. Pay attention to dietary regulation, especially to control the intake of iodine, and eat less food with high iodine content, such as kelp, nori and sea fish, and avoid spicy. Ensure sufficient rest and maintain mental health. It is recommended that patients seek timely medical treatment, standardized treatment.