Heart transplantation is a means of treating severe heart failure or cardiomyopathy, and the survival rate after surgery cannot be generalized because a heart transplant is a foreign body to the patient, and the human body has the instinct of exclusion. After surgery, the patient has to take anti-rejection medication for a long time, and if no rejection occurs, he or she can basically survive like a normal person. Maintaining good living habits after surgery is also the key to prolonging the life of the heart, such as not smoking, not drinking, not staying up late and exercising appropriately. It also depends on one’s own qualities. If there is no atherosclerosis, there is no problem to survive for 20 years after heart transplantation. If the atherosclerosis itself is more serious, it can also produce myocardial ischemia and affect the life of the heart. If the postoperative maintenance can control the elevation of blood lipids, the patient can even survive for more than 30 years.