Folic acid is recommended during the period of preparation for pregnancy. For those who have a plan to prepare for pregnancy, before folic acid, in addition to the need to do the appropriate pre-pregnancy examination as well as a variety of preparations, and at the same time also need to take oral folic acid. In the early stages of pregnancy, the fetal neural tube synthesis of the basic substances is folic acid, if the body does not have a high level of folic acid, it is very easy to cause fetal neural tube malformation, anencephaly or spina bifida, etc., seriously affecting the neural development of the fetus. Therefore, taking folic acid in preparation for pregnancy can play a role in preventing the emergence of these conditions, so should be taken as much as possible, and at the same time in pregnancy also need to increase the intake of folic acid-rich foods, such as spinach, asparagus, broccoli, animal liver, etc., to prevent the folic acid bias during pregnancy.