Sleeping with stomach rumbling and stomach area difficult may be gastritis, peptic ulcer, gastrointestinal dysfunction, dyspepsia and so on. 1. Gastritis and peptic ulcer: can be caused by long-term dietary irregularities, spicy, stimulating, greasy food or drugs, Helicobacter pylori infection. There may be obvious feeling of fullness after meals, discomfort in the stomach area during fasting, accompanied by abdominal pain, bloating, belching, nausea, vomiting and other manifestations. Generally can use gastric mucosa protector, acid inhibitor and other medications, at the same time pay attention to the usual diet, regular meals, light diet. If there is Helicobacter pylori infection can be eradicated using the quadruple method, i.e., a proton pump inhibitor such as omeprazole + a bismuth agent such as colloidal bismuth + two antibiotics such as amoxicillin and clarithromycin. 2. Gastrointestinal dysfunction and dyspepsia: patients with gastrointestinal dysfunction and dyspepsia will also experience hyperactive bowel sounds and discomfort in the stomach area due to decreased digestive function. Gastrointestinal stimulants such as domperidone should be taken to relieve symptoms. Of course, there may be other reasons for stomach rumbling and stomach area discomfort during sleep. If the symptoms recur, it is recommended to go to the hospital to find out the cause and standardize the treatment.