Erizal and Irico are the trade names of Gefitinib tablets, the difference between the two is mainly due to the different manufacturers and prices, the specific use of medication should follow the doctor’s instructions. The former is the imported original drug of Gefitinib tablets, while the latter is the domestic generic drug of Gefitinib tablets, both of which are suitable for the treatment of locally advanced or metastatic non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) gene-sensitive mutations. The manufacturers of the two drugs are different, and the price of the domestic generic drug is lower than that of the imported original drug. However, both drugs have the same active ingredients, specifications and dosage, and are legal and regular clinical drugs, and there is no authoritative statistical data on the comparison of the efficacy of the two drugs. In addition, it should be noted that Gefitinib tablets are prohibited for people who are allergic to it, and there may be diarrhea, rash and other adverse reactions during the use of the drug. To sum up, those who have the need to use Gefitinib tablets should choose and standardize the use of the two drugs under the guidance of a doctor and according to the actual situation of the individual, and should not blindly take the drug or increase or decrease the dosage of the drug on their own, so as not to cause adverse consequences.