Sudden discontinuation of entecavir has the potential to cause an increase in viral load, worsening of liver damage, affecting the treatment of the disease, and even the risk of severe hepatitis. Entecavir is an antiviral drug clinically mainly used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, or fibrotic lesions shown in liver tissue. It should be used according to the course of treatment under the guidance of a doctor, if you suddenly stop taking the drug, there may be a sudden increase in viral load, liver damage, affecting the therapeutic effect of the drug on the disease, and even the emergence of severe hepatitis. It is recommended to use the medication under the guidance of a doctor, do not stop the medication on your own.